Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …

Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including cancer, and is increasingly recognized as a growing cause of preventable cancer …

Abstract γδ T cells are situated at barrier sites and guard the body from infection and
damage. However, little is known about their roles outside of host defense in nonbarrier …

Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

Obesity is an increasingly prevalent disease worldwide. While genetic and environmental
factors are known to regulate the development of obesity and associated metabolic …

Eosinophils in visceral adipose tissue (VAT) have been implicated in metabolic homeostasis
and the maintenance of alternatively activated macrophages (AAMs). The absence of …

Abstract Foxp3+ regulatory T (Treg) cells in visceral adipose tissue (VAT-Treg cells) are
functionally specialized tissue-resident cells that prevent obesity-associated inflammation …

Obesity is driven by chronic low-grade inflammation resulting from dysregulated immune cell
accumulation and function in white adipose tissue (WAT). Interleukin-33 (IL-33) is a key …

The immune system is responsible for defending an organism against the myriad of
microbial invaders it constantly confronts. It has become increasingly clear that the immune …

Group 2 innate lymphoid cells (ILC2s) and regulatory T (Treg) cells are systemically induced
by helminth infection but also sustain metabolic homeostasis in adipose tissue and …