Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …

Recent advances have provided substantial insight into the maintenance of mucosal
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …

Long noncoding RNAs (lncRNAs) are increasingly appreciated as regulators of cell-specific
gene expression. Here, an enhancer-like lncRNA termed NeST (nettoie Salmonella pas …

We present a systematic review of pleiotropy among SNPs and genes reported to show
genome-wide association with common complex diseases and traits. We find abundant …

Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …

In the past decade, there have been fundamental advances in our understanding of genetic
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …

Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically,
pathologically, and therapeutically connected, but little is known about their shared genetic …

Diabetes impacts approximately 200 million people worldwide, of whom approximately 10%
are affected by type 1 diabetes (T1D). The application of genome-wide association studies …

Background Sex differences in incidence and/or presentation of schizophrenia (SCZ), major
depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for …

For the identification of susceptibility loci for primary biliary cirrhosis (PBC), a genome-wide
association study (GWAS) was performed in 963 Japanese individuals (487 PBC cases and …