More than two decades have elapsed since the publication of the first genome sequence of
Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine …

Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …

Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of
drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control …

With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug
targets for antibacterial drug discovery and development. Filamentous temperature sensitive …

In recent years, the rise of antibiotic resistance has become a primary health problem. With
the emergence of bacterial resistance, the need to explore and develop novel antibacterial …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant pathogen of
acute clinical importance. Combination treatment with an FtsZ inhibitor potentiates the …

In search for new molecular entities as anti-TB agents, the benzimidazoquinazoline
polyheterocyclic scaffold has been designed adopting the scaffold hopping strategy. Thirty …

Addressing the growing problem of antibiotic resistance requires the development of new
drugs with novel antibacterial targets. FtsZ has been identified as an appealing new target …