Single-cell or single-nucleus transcriptomics is a powerful tool for identifying cell types and
cell states. However, hypotheses derived from these assays, including gene expression …

Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer's disease (AD),
with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that …

Organoids are self-organized, three-dimensional structures derived from stem cells that can
mimic the structure and physiology of human organs. Patient-specific induced pluripotent …

The complexity of the human brain makes it challenging to understand the molecular
mechanisms underlying brain function. Genome-wide association studies have uncovered …

In this manuscript, we introduced a French EOAD patient in Korea who carried the presenilin-
1 (PSEN1) Glu318Gly mutations with four possible risk variants, including sortilin-related …

Cytoplasmic mislocalization and aggregation of the RNA-binding protein TDP-43 is a
pathological hallmark of the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS) …

Immuno-neurology is an emerging therapeutic strategy for dementia and neurodegeneration
designed to address immune surveillance failure in the brain. Microglia, as central nervous …

The prevalence of neurodegenerative diseases (NDs) is increasing rapidly as the aging
population accelerates, and there are still no treatments to halt or reverse the progression of …

Substantial advances in technology are permitting a high resolution understanding of the
salience of glia, and have helped us to transcend decades of predominantly neuron‐centric …

Neurological monogenic loss-of-function diseases are hereditary disorders resulting from
gene mutations that decrease or abolish the normal function of the encoded protein. These …