As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is
a ligand-activated transcription factor that plays a crucial role in the metabolism of …

The vitamin K antagonist is a commonly prescribed effective oral anticoagulant with a
narrow therapeutic range, and the dose requirements for different patients varied greatly. In …

Efavirenz (EFV), a widely prescribed antiviral medication, has been implicated in
dyslipidemia and can activate the pregnane X receptor (PXR), leading to hepatic steatosis …

Vitamins K exert a range of activities that extend far beyond coagulation and include anti-
inflammatory effects, but the mechanisms involved in anti-inflammatory action remain …

This review explores the likely clinical impact of Pregnane X Receptor (PXR) activation by
vitamin K on human health. PXR, initially recognized as a master regulator of xenobiotic …

A major revelation of genome-scale biological studies in the post-genomic era has been that
two-thirds of human genes do not encode proteins. The majority of non-coding RNA …

K vitamins are well known as essential cofactors for hepatic γ-carboxylation of coagulation
factors, but their potential role in chronic diseases including cancer is understudied. K2, the …

Late-onset hypogonadism, a male age-related syndrome characterized by a decline in
testosterone production in the testes, is commonly treated with testosterone replacement …

With the widespread clinical use of drug combinations, the incidence of drug–drug
interactions (DDI) has significantly increased, accompanied by a variety of adverse …

Vitamins K exert a range of activities that extend far beyond coagulation and include anti-
inflammatory effects, but the mechanisms involved in anti-inflammatory action remain …