Background The mainstay of therapy for many neurodegenerative dementias still relies on
acetylcholinesterase inhibitors (AChEI); however, there is debate on various aspects of such …

Background: In 1986, the Consortium to Establish a Registry for Alzheimer's Disease
(CERAD) was mandated to develop a brief neuropsychological assessment battery (CERAD …

Background: Perfusion imaging has the potential to identify neurodegenerative disorders in
a preclinical stage. However, to correctly interpret perfusion-derived parameters, the impact …

Introduction Donepezil enhances the function of cholinergic nerves by increasing the
concentration of acetylcholine, thereby improving clinical symptoms in patients with …

Aims Cerebral hypometabolism occurs years prior to a diagnosis of neurodegenerative
diseases and coincides with reduced cerebral perfusion and declining noradrenergic …

Imaging and fluid biomarkers are increasingly being used in clinical practice to diagnose
Alzheimer's disease. These biomarkers can detect the presence of amyloid-beta, tau and …

Subjective Cognitive Decline (SCD) is increasingly recognized as an efficient concept to
study in an early preclinical stage of Alzheimer's disease (AD). It is marked by a perceived …

Neurogastroenterology is a subspecialty of gastroenterology that overlaps with neurology.
The enteric nervous system is a collection of neurones that can function independently of the …

Abstract Resting State Functional Magnetic Resonance Imaging (rs-fMRI) is a technique that
is widely used for analyzing brain function using different approaches and methods. This …