Structural aspects of photopharmacology: insight into the binding of photoswitchable and photocaged inhibitors to the glutamate transporter homologue

V Arkhipova, H Fu, MWH Hoorens… - Journal of the …, 2021 - ACS Publications
Photopharmacology addresses the challenge of drug selectivity and side effects through
creation of photoresponsive molecules activated with light with high spatiotemporal …

An AIE polymer prepared via aldehyde-hydrazine step polymerization and the application in Cu2+ and S2− detection

J Huang, H Qin, H Liang, J Lu - Polymer, 2020 - Elsevier
Herein we reported the synthesis of a novel amphiphilic AIE (aggregation-induced emission)
polymer with salicylaldehyde azine (SA) moieties and PEG segments in the backbone via …

Photoswitchable inhibitor of a glutamate transporter

B Cheng, D Shchepakin, MP Kavanaugh… - ACS Chemical …, 2017 - ACS Publications
Excitatory amino acid transporters clear glutamate from the synaptic cleft and play a critical
role in glutamatergic neurotransmission. Their differential roles in astrocytes, microglia, and …

Computational discovery and experimental validation of inhibitors of the human intestinal transporter OATP2B1

N Khuri, AA Zur, MB Wittwer, L Lin… - Journal of chemical …, 2017 - ACS Publications
Human organic anion transporters (OATPs) are vital for the uptake and efflux of drugs and
endogenous compounds. Current identification of inhibitors of these transporters is based …

Identification and Structure–Activity Relationship Study of Imidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 …

P Wu, WE Bjørn-Yoshimoto, M Staudt… - ACS Chemical …, 2019 - ACS Publications
In the present study, screening of a library of 49,087 compounds at the excitatory amino acid
transporter subtype 3 (EAAT3) led to the identification of 2-(furan-2-yl)-8-methyl-N-(o-tolyl) …

Three-component formal metathesis via remote activating strategy enabled (RASE) domino activation of two C (sp 3)–O bonds in alkyl ethers

D Zhuang, L Cheng, Y Yan, Y Tang, Z Wan… - Organic Chemistry …, 2024 - pubs.rsc.org
A remote activating strategy enabled (RASE) three-component formal metathesis among an
alkyl benzyl ether, an alkyl aryl ether and a Brønsted acid is achieved through metal-free …

5-Aryl-2-furaldehydes in the synthesis of tetrahydropyrimidinones by Biginelli reaction

AR Vakhula, YI Horak, RZ Lytvyn, AI Lesyuk… - Chemistry of …, 2018 - Springer
5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with
ethyl acetoacetate or acetylacetone and (thio)-urea in the presence of FeCl 3· 6H 2 O as a …

β-Sulfonamido functionalized aspartate analogues as excitatory amino acid transporter inhibitors: distinct subtype selectivity profiles arising from subtle structural …

JC Hansen, WE Bjørn-Yoshimoto… - Journal of Medicinal …, 2016 - ACS Publications
In this study inspired by previous work on 3-substituted Asp analogues, we designed and
synthesized a total of 32 β-sulfonamide Asp analogues and characterized their …

β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs)

N Liu, AA Jensen, L Bunch - ACS Medicinal Chemistry Letters, 2020 - ACS Publications
The excitatory amino acid transporters (EAATs) mediate uptake of the major excitatory
neurotransmitter l-glutamate (Glu). The essential functions governed by these transporters in …

Copper (II) bromide-catalyzed conjugate addition of furans to α, β-unsaturated carbonyl compounds

AA Fadeev, MG Uchuskin, IV Trushkov… - Chemistry of Heterocyclic …, 2017 - Springer
Copper(II) bromide-catalyzed conjugate addition of furans to α,β-unsaturated carbonyl
compounds | SpringerLink Skip to main content Advertisement SpringerLink Log in Menu Find …