Cancer is ranked as the second leading cause of death globally. Traditional cancer
therapies including chemotherapy are flawed, with off-target and on-target toxicities on the …

Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

Abstract Polo-like kinase 1 (Plk1) overexpression has been shown to occur in a wide range
of tumors, prompting research and development of Plk1 inhibitors as a means of cancer …

Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …

Cell proliferation is an essential mechanism for growth, development and regeneration of
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …

The strategy of clinically targeting cancerous cells at their most vulnerable state during
mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway. As the …

One of the most promising developments in translational cancer medicine has been the
emergence of circulating tumor cells (CTC) as a minimally invasive multifunctional …

Polo-like kinases (Plks) are a family of serine-threonine kinases that regulate multiple
intracellular processes including DNA replication, mitosis, and stress response. Plk1, the …

Breast cancers are composed of molecularly distinct subtypes with different clinical
outcomes and responses to therapy. To discover potential therapeutic targets for the poor …

Mitosis represents a promising target to block cancer cell proliferation. Classical antimitotics,
mainly microtubule-targeting agents (MTAs), such as taxanes and vinca alkaloids, are …