The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

Regulation of gene expression is critical in determining cell identity, development, and
responses to the cellular environment. DNA is the inherited source of genetic information …

Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs longer than 200
nucleotides (nt). LncRNAs have high spatiotemporal specificity, and secondary structures …

Following the initial discovery of the heat shock RNA omega (hsrω) gene of Drosophila
melanogaster to be non‐coding (nc) and also inducible by cell stress, other stress‐inducible …

U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing
spliceosome, is heavily modified post-transcriptionally, with 2′-O-methylation being most …

The non-coding RNA 7SK is the scaffold for a small nuclear ribonucleoprotein (7SKsnRNP)
which regulates the function of the positive transcription elongation factor P-TEFb in the …

Avoiding excessive or insufficient immune responses and maintaining homeostasis are
critical for animal survival. Although many positive or negative modulators involved in …

Genomic analysis has found that the transcriptome in both humans and Drosophila
melanogaster features large numbers of long non-coding RNA transcripts (lncRNAs). This …

The positive transcription elongation factor (P-TEFb) is required for the transcription of most
genes by RNA polymerase II. Hexim proteins associated with 7SK RNA bind to P-TEFb and …

Abstract The Drosophila Toll signaling pathway mainly responds to Gram-positive (G+)
bacteria or fungal infection, which is highly conserved with mammalian TLR signaling …