Type 2 diabetes mellitus (T2DM) is regarded as one of the most severe chronic metabolic
diseases worldwide, which poses a great threat to human safety and health. The main …

An imbalance in microbial homeostasis, referred to as dysbiosis, is critically associated with
the progression of obesity-induced metabolic disorders including type 2 diabetes (T2D) …

Introduction Many clinical studies have proved the effectiveness of probiotics in metabolic
disorders associated with insulin resistance. However, the impact of probiotic therapy on …

Abstract β-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we
found that trimethylamine N-oxide (TMAO) at a similar concentration to that found in diabetes …

Diabetes mellitus (DM) is a serious metabolic disease characterized by persistent
hyperglycemia, with a continuously increasing morbidity and mortality. Although traditional …

Simple Summary The objective of this study was to define the role of the transcription factor
CEBPA on pancreatic beta cell function, replication, and survival. We have previously shown …

Metabolic syndrome mainly includes obesity, type 2 diabetes (T2DM), alcoholic fatty liver
(NAFLD) and cardiovascular diseases. According to the ancient experience philosophy of …

The gut microbial metabolite trimethylamine N-oxide (TMAO) has received increased
attention due to its close relationship with cardiovascular disease and type 2 diabetes. In …

Pancreatic beta cells play a critical role in maintaining glucose homeostasis by serving as
the primary source of insulin. These cells are responsible for the synthesis, storage, and …

Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite, the production of
which in vivo is mainly regulated by dietary choices, gut microbiota, and the hepatic enzyme …