Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs
in a number of organs, including the lungs. Cellular metabolism regulates tissue repair and …

Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the
formation and development of cancer cells. It plays a central role in three cyclic processes …

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …

Cutaneous fibrosis results from suboptimal wound healing following significant tissue injury
such as severe burns, trauma, and major surgeries. Pathologic skin fibrosis results in scars …

Despite remarkable responses to cancer immunotherapy in a subset of patients, many
patients remain resistant to these therapies. The tumor microenvironment can impose …