Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury

ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …

A structural view of miRNA biogenesis and function

AL Leitão, FJ Enguita - Non-coding RNA, 2022 - mdpi.com
Micro-RNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) that act as post-
transcriptional regulators of gene expression. Since their discovery in 1993, they have been …

MirGeneDB 2.1: toward a complete sampling of all major animal phyla

B Fromm, E Høye, D Domanska, X Zhong… - Nucleic acids …, 2022 - academic.oup.com
We describe an update of MirGeneDB, the manually curated microRNA gene database.
Adhering to uniform and consistent criteria for microRNA annotation and nomenclature, we …

A uniform system for the annotation of vertebrate microRNA genes and the evolution of the human microRNAome

B Fromm, T Billipp, LE Peck, M Johansen… - Annual review of …, 2015 - annualreviews.org
Although microRNAs (miRNAs) are among the most intensively studied molecules of the
past 20 years, determining what is and what is not a miRNA has not been straightforward …

Evolution of microRNA diversity and regulation in animals

E Berezikov - Nature Reviews Genetics, 2011 - nature.com
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …

MirGeneDB 2.0: the metazoan microRNA complement

B Fromm, D Domanska, E Høye… - Nucleic Acids …, 2020 - academic.oup.com
Small non-coding RNAs have gained substantial attention due to their roles in animal
development and human disorders. Among them, microRNAs are special because …

MicroRNA control of signal transduction

M Inui, G Martello, S Piccolo - Nature reviews Molecular cell biology, 2010 - nature.com
MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene
expression. After the identification of hundreds of miRNAs, the challenge is now to …

The roles of microRNAs in mouse development

B DeVeale, J Swindlehurst-Chan… - Nature Reviews Genetics, 2021 - nature.com
Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns
during embryonic and postnatal mouse development. The loss of all miRNAs through the …

The evolution of gene regulation by transcription factors and microRNAs

K Chen, N Rajewsky - Nature Reviews Genetics, 2007 - nature.com
Abstract Changes in the patterns of gene expression are widely believed to underlie many of
the phenotypic differences within and between species. Although much emphasis has been …

The evolutionary origin of plant and animal microRNAs

Y Moran, M Agron, D Praher, U Technau - Nature ecology & evolution, 2017 - nature.com
MicroRNAs (miRNAs) are a unique class of short endogenous RNAs, which have become
known in the past few decades as major players in gene regulation at the post …