Stem cell biology has come of age. Unequivocal proof that stem cells exist in the
haematopoietic system has given way to the prospective isolation of several tissue-specific …

A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …

Although the existence of mammary stem cells has been suggested by serial transplantation
studies in mice, their identification has been hindered by the lack of specific surface markers …

Pediatric brain tumors are significant causes of morbidity and mortality. It has been
hypothesized that they derive from self-renewing multipotent neural stem cells. Here, we …

The emerging field of regenerative medicine will require a reliable source of stem cells in
addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue has proven to …

Epigenetic genome modifications are thought to be important for specifying the lineage and
developmental stage of cells within a multicellular organism. Here, we show that the …

The 293 cell line was derived by transformation of primary cultures of human embryonic
kidney (HEK) cells with sheared adenovirus (Ad) 5 DNA. A combination of immunostaining …

▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …

The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were
compared to define a genetic program for stem cells. A total of 216 genes are enriched in all …

Solid tumors arise in organs that contain stem cell populations. The tumors in these tissues
consist of heterogeneous populations of cancer cells that differ markedly in their ability to …