Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence
NR Coelho, AB Pimpão, MJ Correia… - Journal of Molecular …, 2022 - Springer
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that can be
activated by structurally diverse compounds arising from the environment and the microbiota …
activated by structurally diverse compounds arising from the environment and the microbiota …
Tackling drug resistance with efflux pump inhibitors: from bacteria to cancerous cells
RC Lowrence, SG Subramaniapillai… - Critical reviews in …, 2019 - Taylor & Francis
Drug resistance is a serious concern in a clinical setting jeopardizing treatment for both
infectious agents and cancers alike. The wide-spread emergence of multi-drug resistant …
infectious agents and cancers alike. The wide-spread emergence of multi-drug resistant …
Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate …
Emerging evidence links exosomes to cancer progression by the trafficking of oncogenic
factors and neoplastic reprogramming of stem cells. This necessitates identification and …
factors and neoplastic reprogramming of stem cells. This necessitates identification and …
Anticancer effects of asiatic acid against doxorubicin-resistant breast cancer cells via an AMPK-dependent pathway in vitro
Background and purpose Asiatic acid is one of the active compounds isolated from Centella
asiatica and has been used to treat many diseases, including hypertension, pulmonary …
asiatica and has been used to treat many diseases, including hypertension, pulmonary …
Gadolinium‐doped iron oxide nanoprobe as multifunctional bioimaging agent and drug delivery system
G Zhang, R Du, L Zhang, D Cai, X Sun… - Advanced Functional …, 2015 - Wiley Online Library
In this study, a high‐performance T1–T2 dual‐model contrast agent by gadolinium‐doped
iron oxide nanoparticle (GION) is developed. Following its development, the application of …
iron oxide nanoparticle (GION) is developed. Following its development, the application of …
Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF‐7 …
C Yuan, G Chen, C Jing, M Liu, B Liang… - … of Biochemical and …, 2022 - Wiley Online Library
Eriocitrin, a lemons flavanone, exhibits several biological properties, antiproliferative, and
proapoptotic effects. However, its molecular mechanical action is not entirely clarified …
proapoptotic effects. However, its molecular mechanical action is not entirely clarified …
[HTML][HTML] Niban apoptosis regulator 1 promotes gemcitabine resistance by activating the focal adhesion kinase signaling pathway in bladder cancer
S Tong, H Yin, J Fu, Y Li - Journal of Cancer, 2022 - ncbi.nlm.nih.gov
Although intravesical gemcitabine (GEM) chemotherapy (IGC) can effectively reduce the
recurrence risk of non-muscle invasive bladder cancer (NMIBC), the development of GEM …
recurrence risk of non-muscle invasive bladder cancer (NMIBC), the development of GEM …
Synthesis and structure-activity relationship studies of α-naphthoflavone derivatives as CYP1B1 inhibitors
Abstract Cytochrome P450 1B1 (CYP1B1) has been recognized as an important target for
cancer prevention and drug resistance reversal. In order to obtain potent and selective …
cancer prevention and drug resistance reversal. In order to obtain potent and selective …
Discovery of heterocycle-containing α-naphthoflavone derivatives as water-soluble, highly potent and selective CYP1B1 inhibitors
Abstract Cytochrome P450 1B1 (CYP1B1) has been well validated as an attractive target for
cancer prevention and drug resistance reversal. In continuation of our interest in this area …
cancer prevention and drug resistance reversal. In continuation of our interest in this area …
Nelfinavir targets multiple drug resistance mechanisms to increase the efficacy of doxorubicin in MCF-7/Dox breast cancer cells
G Chakravarty, A Mathur, P Mallade, S Gerlach, J Willis… - Biochimie, 2016 - Elsevier
Abstract Development of multidrug resistance (MDR) remains a significant problem in
cancer chemotherapy and underscores the importance of using chemosensitizers. Well …
cancer chemotherapy and underscores the importance of using chemosensitizers. Well …