Vaccination is one of the most efficient strategies for the prevention of infectious diseases.
Although safer, subunit vaccines are poorly immunogenic and for this reason the use of …

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …

Signals controlling the generation of regulatory B (Breg) cells remain ill-defined. Here we
report an" auto"-regulatory feedback mechanism between plasmacytoid dendritic cells …

Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …

In the decade since the discovery that mouse B cells respond to certain unmethylated CpG
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …

Abstract Toll-like receptor 9 (TLR9) is a pattern recognition receptor that is predominantly
located intracellularly in immune cells, including dendritic cells, macrophages, natural killer …

Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that
express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells …

Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger
an immunomodulatory cascade that involves B and T cells, natural killer cells and …

Toll-like receptors (TLRs) have a crucial role in the early detection of pathogen-associated
molecular patterns and the subsequent activation of the adaptive immune response …

CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses,
yet little is understood about how these cells are regulated. We describe a mechanism …