Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds

P Pan, PJ Tonge - Current topics in medicinal chemistry, 2012 - ingentaconnect.com
The bacterial type II fatty acid biosynthesis (FASII) pathway is an essential but unexploited
target for drug discovery. In this review we summarize SAR studies on inhibitors of InhA, the …

Nanotechnology-based drug delivery systems for treatment of tuberculosis—a review

PB Da Silva, ES de Freitas, J Bernegossi… - Journal of …, 2016 - ingentaconnect.com
Tuberculosis (TB) is an infectious and transmissible disease that is caused by
Mycobacterium tuberculosis and primarily affects the lungs, although it can affect other …

Hydroxyquinoline derived vanadium (IV and V) and copper (II) complexes as potential anti-tuberculosis and anti-tumor agents

I Correia, P Adao, S Roy, M Wahba, C Matos… - Journal of inorganic …, 2014 - Elsevier
Several mixed ligand vanadium and copper complexes were synthesized containing 8-
hydroxyquinoline (8HQ) and a ligand such as picolinato (pic−), dipicolinato (dipic 2−) or a …

Ru (II)-based complexes with N-(acyl)-N′, N′-(disubstituted) thiourea ligands: Synthesis, characterization, BSA-and DNA-binding studies of new cytotoxic agents …

RS Correa, KM de Oliveira, FG Delolo, A Alvarez… - Journal of inorganic …, 2015 - Elsevier
Four ruthenium (II)-based complexes with N-(acyl)-N′, N′-(disubstituted) thiourea
derivatives (Th) were obtained. The compounds, with the general formula trans-[Ru (PPh 3) …

Ruthenium (II)-diphosphine complexes containing acylthiourea ligands are effective against lung and breast cancers

GF Grawe, KM Oliveira, CM Leite, TD de Oliveira… - Dalton …, 2022 - pubs.rsc.org
We have synthesized and characterized three new ruthenium (II) diphosphine complexes
containing an acylthiourea ligand, with the general formula [Ru (DPEPhos)(O, S)(bipy)] PF6 …

Selective anticancer copper(ii)-mixed ligand complexes: targeting of ROS and proteasomes

CH Ng, SM Kong, YL Tiong, MJ Maah, N Sukram… - Metallomics, 2014 - academic.oup.com
Copper compounds can be alternatives to platinum-based anticancer drugs. This study
investigated the effects of a series of ternary copper (ii) complexes,[Cu (phen)(aa)(H2O)] …

Ruthenium (II) phosphine/diimine/picolinate complexes: Inorganic compounds as agents against tuberculosis

FR Pavan, GV Poelhsitz, MIF Barbosa… - European Journal of …, 2011 - Elsevier
This paper describes the synthesis and characterization of four new ruthenium complexes
containing 1, 4 bis (diphenylphosphino) butane (dppb), 2-pyridinecarboxylic acid anion (pic) …

Ruthenium (II) complexes of 1, 3-thiazolidine-2-thione: Cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with …

RS Corrêa, MM da Silva, AE Graminha… - Journal of inorganic …, 2016 - Elsevier
Three new mixed and mononuclear Ru (II) complexes containing 1, 3-thiazolidine-2-thione
(tzdtH) were synthesized and characterized by spectroscopic analysis, molar conductivity …

In vitro cytotoxicity and in vivo zebrafish toxicity evaluation of Ru (ii)/2-mercaptopyrimidine complexes

VS Velozo-Sá, LR Pereira, AP Lima… - Dalton …, 2019 - pubs.rsc.org
In this paper, four new ruthenium complexes,[Ru (N–S)(dppm) 2] PF6 (1),[Ru (N–S)(dppe) 2]
PF6 (2),[Ru (N–S) 2 (dppp)](3) and [Ru (N–S) 2 (PPh3) 2](4)[dppm= 1, 1-bis …

Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd (C2, N-dmba)(Br)(tu)](dmba= N, N-dimethylbenzylamine, tu= thiourea)

AC Moro, AE Mauro, AVG Netto, SR Ananias… - European Journal of …, 2009 - Elsevier
The reactions between [Pd (C2, N-dmba)(μ-X)] 2 (dmba= N, N-dimethylbenzylamine; X= Cl,
Br) and thiourea (tu) in the 1: 2 molar ratio at room temperature resulted in the mononuclear …