Abstract Interferon‐γ (IFN‐γ) is crucial for immunity against intracellular pathogens and for
tumor control. However, aberrant IFN‐γ expression has been associated with a number of …

In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from
eating disorders to rabies. However, as newer, more effective drugs were discovered and as …

The etiology of disease pathogenesis can be largely explained by genetic variations and
several types of environmental factors. In genetically disease-susceptible individuals …

Susceptibility to type 1 diabetes is associated strongly with human leucocyte antigen (HLA)
genes, implicating T cells in disease pathogenesis. In humans, CD8 T cells predominantly …

T cell–mediated loss of insulin-secreting β cells in the islets of Langerhans is the hallmark of
type 1 diabetes. The molecular basis for the directed migration of autoreactive T cells …

Sjögren's syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry
mouth), keratoconjunctivitis sicca (eye dryness), and other systematic disorders. Its …

Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-
producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is …

Emerging and re-emerging viral diseases have increased in number and geographical
extent during the last decades. Examples include the current COVID-19 pandemic and the …

Abstract Type 1 diabetes (T1D), an autoimmune disease once thought to be mediated
exclusively by β cell-specific CD4+ T cells, is now recognized as one in which autoreactive …

Activated insulin-specific CD8+ T cells (IS-CD8+ cells) home to the pancreas, destroy β
cells, and cause rapid diabetes upon transfer into diabetes-prone NOD mice. Surprisingly …