Human APOBEC3 variations and viral infection
S Sadeghpour, S Khodaee, M Rahnama, H Rahimi… - Viruses, 2021 - mdpi.com
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
The current toolbox for APOBEC drug discovery
MJ Grillo, KFM Jones, MA Carpenter, RS Harris… - Trends in …, 2022 - cell.com
Mutational processes driving genome evolution and heterogeneity contribute to immune
evasion and therapy resistance in viral infections and cancer. APOBEC3 (A3) enzymes …
evasion and therapy resistance in viral infections and cancer. APOBEC3 (A3) enzymes …
APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection
L Manjunath, S Oh, P Ortega, A Bouin… - Nature …, 2023 - nature.com
Double-stranded RNA produced during viral replication and transcription activates both
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …
The cytidine deaminase APOBEC3G contributes to cancer mutagenesis and clonal evolution in bladder cancer
Mutagenic processes leave distinct signatures in cancer genomes. The mutational
signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers …
signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers …
Mechanistic insight into antiretroviral potency of 2′-deoxy-2′-β-fluoro-4′-azidocytidine (FNC) with a long-lasting effect on HIV-1 prevention
L Sun, Y Peng, W Yu, Y Zhang, L Liang… - Journal of Medicinal …, 2020 - ACS Publications
In preclinical and phase I and II clinical studies, 2′-deoxy-2′-β-fluoro-4′-azidocytidine
(FNC) displays a potent and long-lasting inhibition of HIV-1 infection. To investigate its …
(FNC) displays a potent and long-lasting inhibition of HIV-1 infection. To investigate its …
Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure
YZ McDaniel, D Wang, RP Love… - Nucleic acids …, 2020 - academic.oup.com
The human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3,
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state
Abstract APOBEC3 proteins (A3s) are enzymes that catalyze the deamination of cytidine to
uridine in single-stranded DNA (ssDNA) substrates, thus playing a key role in innate antiviral …
uridine in single-stranded DNA (ssDNA) substrates, thus playing a key role in innate antiviral …
Examination of the APOBEC3 barrier to cross species transmission of primate lentiviruses
The transmission of viruses from animal hosts into humans have led to the emergence of
several diseases. Usually these cross-species transmissions are blocked by host restriction …
several diseases. Usually these cross-species transmissions are blocked by host restriction …
Stability of APOBEC3F in the presence of the APOBEC3 antagonist HIV-1 vif increases at the expense of co-expressed APOBEC3H haplotype I
The seven human APOBEC3 enzymes (APOBEC3A through H, excluding E) are host
restriction factors. Most of the APOBEC3 enzymes can restrict HIV-1 replication with different …
restriction factors. Most of the APOBEC3 enzymes can restrict HIV-1 replication with different …
Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity
APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-
stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and …
stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and …