The design of protein–protein interfaces using physics-based design methods such as
Rosetta requires substantial computational resources and manual refinement by expert …

Four, eight or twenty C3 symmetric protein trimers can be arranged with tetrahedral (T-sym),
octahedral (O-sym) or icosahedral (I-sym) point group symmetry to generate closed cage …

Polyhedral protein nanocages have had considerable success as vaccine platforms (1–3)
and are promising vehicles for biologics delivery (4–7). Hence there is considerable interest …