Lower urinary tract dysfunction in the neurological patient: clinical assessment and management

JN Panicker, CJ Fowler, TM Kessler - The Lancet Neurology, 2015 - thelancet.com
Lower urinary tract (LUT) dysfunction is a common sequela of neurological disease,
resulting in symptoms that have a pronounced effect on quality of life. The site and nature of …

Voiding dysfunction due to detrusor underactivity: an overview

MJ Drake, J Williams, DA Bijos - Nature Reviews Urology, 2014 - nature.com
Detrusor underactivity (DUA) is defined as a voiding contraction of reduced strength and/or
duration, which prolongs urination and/or prevents complete emptying of the bladder within …

Voluntary urination control by brainstem neurons that relax the urethral sphincter

JA Keller, J Chen, S Simpson, EHJ Wang… - Nature …, 2018 - nature.com
Voluntary urination ensures that waste is eliminated when safe and socially appropriate,
even without a pressing urge. Uncontrolled urination, or incontinence, is a common problem …

Contemporary concepts in the aetiopathogenesis of detrusor underactivity

NI Osman, CR Chapple - Nature Reviews Urology, 2014 - nature.com
Detrusor underactivity (DUA) is a poorly understood, yet common, bladder dysfunction,
referred to as underactive bladder, which is observed in both men and women undergoing …

Topical neurological stimulation

GH Creasey, H Toong - US Patent 10,016,600, 2018 - Google Patents
A topical nerve stimulator patch and system are provided comprising a dermal patch; an
electrical signal generator associated with the patch; a signal receiver to activate the …

Neurogenic lower urinary tract dysfunction: evaluation and management

KI Tudor, R Sakakibara, JN Panicker - Journal of neurology, 2016 - Springer
The lower urinary tract (LUT) in health is regulated by coordinated multi-level neurological
inputs which require an intact central and peripheral nervous system. Lower urinary tract …

Impact of bioelectronic medicine on the neural regulation of pelvic visceral function

WC de Groat, C Tai - Bioelectronic medicine, 2015 - Springer
Neuromodulation elicited by electrical stimulation of peripheral or spinal nerves is a US
Food and Drug Administered (FDA)-approved therapy for treating disorders of the pelvic …

Scan-negative cauda equina syndrome: a prospective cohort study

I Hoeritzauer, A Carson, P Statham, JN Panicker… - Neurology, 2021 - AAN Enterprises
Objective To describe clinical features relevant to diagnosis, mechanism, and etiology in
patients with “scan-negative” cauda equina syndrome (CES). Methods We carried out a …

Mechanism of action of botulinum toxin A in treatment of functional urological disorders

YH Lin, BJ Chiang, CH Liao - Toxins, 2020 - mdpi.com
Intravesical botulinum toxin (BoNT) injection is effective in reducing urgency and urinary
incontinence. It temporarily inhibits the detrusor muscle contraction by blocking the release …

The therapeutic effects and pathophysiology of botulinum toxin A on voiding dysfunction due to urethral sphincter dysfunction

YL Kao, KH Huang, HC Kuo, YC Ou - Toxins, 2019 - mdpi.com
Neurogenic and non-neurogenic urethral sphincter dysfunction are common causes of
voiding dysfunction. Injections of botulinum toxin A (BoNT-A) into the urethral sphincter have …