Mitigating RNA toxicity in myotonic dystrophy using small molecules
This review, one in a series on myotonic dystrophy (DM), is focused on the development and
potential use of small molecules as therapeutics for DM. The complex mechanisms and …
potential use of small molecules as therapeutics for DM. The complex mechanisms and …
Balamuthia mandrillaris: pathogenesis, diagnosis, and treatment
MR Mungroo, NA Khan, R Siddiqui - Expert Opinion on Orphan …, 2020 - Taylor & Francis
Introduction: Balamuthia mandrillaris is known to cause a fatal infection of the central
nervous system termed granulomatous amoebic encephalitis (GAE). Cases of GAE by B …
nervous system termed granulomatous amoebic encephalitis (GAE). Cases of GAE by B …
[HTML][HTML] Evaluation of the antichagasic activity of batroxicidin, a cathelicidin-related antimicrobial peptide found in Bothrops atrox venom gland
CP Mello, DB Lima, ICJ Bandeira, LD Tessarolo… - Toxicon, 2017 - Elsevier
Antimicrobial peptides (AMPs) are potential alternatives to conventional antibiotics, as they
have a fast mode of action, a low likelihood of resistance development and can act in …
have a fast mode of action, a low likelihood of resistance development and can act in …
Design, synthesis, antitrypanosomal activity, DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles
Novel imidazoline benzimidazole derivatives containing diversely substituted phenoxy
moieties were synthesized with the aim of evaluating their antitrypanosomal activity …
moieties were synthesized with the aim of evaluating their antitrypanosomal activity …
New quinoline-arylamidine hybrids: Synthesis, DNA/RNA binding and antitumor activity
Four series of new hybrid molecules with 7-chloroquinoline and arylamidine moieties joined
through the rigid-O-(groups I (2a-g) and II (5a-g)) or flexible-NH-CH 2-CH 2-O-(groups III (8a …
through the rigid-O-(groups I (2a-g) and II (5a-g)) or flexible-NH-CH 2-CH 2-O-(groups III (8a …
[HTML][HTML] Antichagasic effect of hemocyanin derived from antimicrobial peptides of penaeus monodon shrimp
ML Monteiro, DB Lima, TL Sampaio, BP Silva… - Experimental …, 2020 - Elsevier
Trypanosoma cruzi, the etiological agent of Chagas disease, is responsible for the infection
of millions of people worldwide and it is a public health problem, without an effective cure …
of millions of people worldwide and it is a public health problem, without an effective cure …
Recruitment kinetics of the homologous recombination pathway in procyclic forms of Trypanosoma brucei after ionizing radiation treatment
One of the most important mechanisms for repairing double-strand breaks (DSBs) in model
eukaryotes is homologous recombination (HR). Although the genes involved in HR have …
eukaryotes is homologous recombination (HR). Although the genes involved in HR have …
Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections
M Rivara-Espasandín, MC Palumbo, EJ Sosa… - Frontiers in …, 2023 - frontiersin.org
Introduction: Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp., commonly
referred to as TriTryps, are a group of protozoan parasites that cause important human …
referred to as TriTryps, are a group of protozoan parasites that cause important human …
Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity
Abstract The novel benzimidazol-2-yl-fur-5-yl-(1, 2, 3)-triazolyl dimeric series with aliphatic
and aromatic central linkers was successfully prepared with the aim of assessing binding …
and aromatic central linkers was successfully prepared with the aim of assessing binding …
2‐Bromo‐2‐chloro‐3‐arylpropanenitriles as C‐3 Synthons for the Synthesis of Functionalized 3‐Aminothiophenes
2‐Bromo‐2‐chloro‐3‐arylpropanenitriles can be prepared by Meerwein reaction from 2‐
chloroacrylonitrile and various aryldiazonium salts under copper (II) bromide catalysis. They …
chloroacrylonitrile and various aryldiazonium salts under copper (II) bromide catalysis. They …