Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

Twenty years ago, the first description of a tristetraprolin (TTP) knockout mouse highlighted
the fundamental role of TTP in the restraint of inflammation. Since then, work from several …

Recent studies have challenged the traditional belief that mature fat cells are irreversibly
differentiated and revealed they can dedifferentiate into fibroblast-like cells known as …

White adipose tissue (WAT) can develop into several phenotypes with different
pathophysiological impact on type 2 diabetes. To better understand the adipogenic process …

We employed transcriptome analysis of epidermal growth factor receptor related gene
expression changes in cellular and animal models of Parkinson's disease (PD). We used a …

Background The tristetraprolin (TTP) family of mRNA-binding proteins contains three major
members, Ttp, Zfp36l1, and Zfp36l2. Ttp down-regulates the stability of AU-rich element …

DNA methylation could provide a link between environmental, genetic factors and weight
control and can modify gene expression pattern. This study aimed to identify genes, which …

The genome of human adipose-derived stem cells (ADSCs) from abdominal and
gluteofemoral adipose tissue depots are maintained in depot-specific stable epigenetic …

Background Turnover of mRNA is a critical step in the regulation of gene expression, and an
important step in mRNA decay is removal of the 5′ cap. We previously demonstrated that …