More than 100 million Americans experience chronic daily pain. 1 Moreover, it is estimated
that more than 65.9 million outpatient surgical procedures are performed in the United …

This paper is the forty-first consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

An expanding body of evidence has established that racial disparities exist in the US
healthcare system, manifesting in poorer health outcomes for members of the non-white …

Prior work considers effects of prescribing restrictions on opioid use but not upstream
implications for pharmaceutical marketing activities, despite the inordinate role many believe …

Abstract Introduction The United States has experienced substantial increases in opioid use
for more than two decades. This growth has impacted rural areas where overdoses have …

Although overall outpatient dispensing of opioid analgesic prescriptions has declined, there
may still be overprescribing. Understanding how many opioid analgesic units, primarily …

Background: Little is known about the evidence required by the US Food and Drug
Administration (FDA) for new approvals of opioid analgesics. Objective: To characterize the …

METHODS We recruited random samples of primary care physicians in Sacramento,
Vancouver, Montreal, and Toulouse (n= 255) to report on consecutive sales visits …

Background: Secretagogues have been introduced as new agents for the treatment of
constipation. Previously published modeling studies suggested that improved productivity …

Acute hepatitis C infection is on the rise in the United States, with a more than twofold
increase in incidence rate from 2003 to 2016 overall and a threefold increase among young …