At the interface of lifestyle, behavior, and circadian rhythms: metabolic implications

SA Bae, MZ Fang, V Rustgi, H Zarbl… - Frontiers in …, 2019 - frontiersin.org
Nutrient metabolism is under circadian regulation. Disruption of circadian rhythms by
lifestyle and behavioral choices such as work schedules, eating patterns, and social jetlag …

Computational modeling of the cell-autonomous mammalian circadian oscillator

OA Podkolodnaya, NN Tverdokhleb… - BMC systems …, 2017 - Springer
This review summarizes various mathematical models of cell-autonomous mammalian
circadian clock. We present the basics necessary for understanding of the cell-autonomous …

Fuzzy stochastic petri nets for modeling biological systems with uncertain kinetic parameters

F Liu, M Heiner, M Yang - PloS one, 2016 - journals.plos.org
Stochastic Petri nets (SPNs) have been widely used to model randomness which is an
inherent feature of biological systems. However, for many biological systems, some kinetic …

The synergistic role of light-feeding phase relations on entraining robust circadian rhythms in the periphery

SA Bae, IP Androulakis - Gene regulation and systems …, 2017 - journals.sagepub.com
The feeding and fasting cycles are strong behavioral signals that entrain biological rhythms
of the periphery. The feeding rhythms synchronize the activities of the metabolic organs …

Deciphering the Role of Circadian Clock in Inflammatory Response and Immune Disorders Using Model Checking and Petri Nets

HU Rahman, J Ahmad, A Akhmediyarova… - IEEE …, 2024 - ieeexplore.ieee.org
Circadian rhythms play a significant role to optimize immunity and combat infections. Any
disturbance of the circadian clock, which is caused by environmental cues or zeitgebers …

Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding

SA Bae, IP Androulakis - American Journal of Physiology …, 2018 - journals.physiology.org
The circadian rhythms influence the metabolic activity from molecular level to tissue, organ,
and host level. Disruption of the circadian rhythms manifests to the host's health as …

[HTML][HTML] Analyzing the behavior of neuronal pathways in alzheimer's disease using Petri net modeling approach

J Ashraf, J Ahmad, A Ali, Z Ul-Haq - Frontiers in neuroinformatics, 2018 - frontiersin.org
Alzheimer's Disease (AD) is the most common neuro-degenerative disorder in the elderly
which leads to dementia. The hallmark of AD is senile lesions made by abnormal …

Modeling and analysis of the impacts of jet lag on circadian rhythm and its role in tumor growth

A Hassan, J Ahmad, H Ashraf, A Ali - PeerJ, 2018 - peerj.com
Circadian rhythms maintain a 24 h oscillation pattern in metabolic, physiological and
behavioral processes in all living organisms. Circadian rhythms are organized as …

Computational modeling and analysis of the impacts of sleep deprivation on glucose stimulated insulin secretion

H Ashraf, J Ahmad, A Hassan, A Ali - Biosystems, 2019 - Elsevier
Circadian clock is an exquisite internal biological clock functioning in all living organisms.
Lifestyle changes such as shift work or frequent travelling might result in malfunctioning of …

Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy

N Azim, J Ahmad, N Iqbal, A Siddiqa… - IET Systems …, 2020 - Wiley Online Library
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle
disease that may result in arrhythmia, heart failure and sudden death. The hallmark …