A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …

Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …

Cancer is one of the most common diseases and causes of death worldwide. Since common
treatment approaches do not yield acceptable results in many patients, developing …

Single domain antibodies from camelids, or nanobodies, are a unique class of antibody
fragments with several advantageous characteristics: small monomeric size, high stability …

By the emergence of recombinant DNA technology, many antibody fragments have been
developed devoid of undesired properties of natural immunoglobulins. Among them …

Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as
Nanobodies®, have changed the landscape of affinity reagents. The outstanding solubility …

Shark is a cartilaginous fish that produces new antigen receptor (IgNAR) antibodies. This
antibody is identified with a similar human heavy chain but dissimilar sequences. The …

ABSTRACT A milestone in the field of recombinant binding molecules was achieved 30
years ago with the discovery of single-domain antibodies from which antigen-binding …

Immunogenicity is a major caveat of protein therapeutics. In particular, the long-term
administration of protein therapeutic agents leads to the generation of antidrug antibodies …

Phage display antibody libraries have proven an invaluable resource for the isolation of
diagnostic and potentially therapeutic antibodies, the latter usually being antibody fragments …