A 'fourth wave'of high mortality involving methamphetamine and cocaine use has been
gathering force in the USA. Availability and use of illicit fentanyls are still the major drivers of …

Background. Drug overdose is an important, yet an inadequately understood, public health
problem. Global attention to unintentional drug overdose has been limited by comparison …

Policy Points This article reconceptualizes our understanding of the opioid epidemic and
proposes six strategies that address the epidemic's social roots. In order to successfully …

Community-based opioid overdose prevention programs (OOPPs) that include the
distribution of naloxone have increased in response to alarmingly high overdose rates in …

Background Socioeconomic marginalization (SEM) is an important but under-explored
determinant of opioid overdose with important implications for health equity and associated …

Background The US population of former prison inmates is large and growing. The period
immediately after release may be challenging for former inmates and may involve …

Background US research examining the illicit drug supply remains rare even though the
information could help reduce overdoses. Relatively little is known regarding how often …

Importance Injection drug use is the primary mode of transmission for hepatitis C virus (HCV)
infection. Prior studies suggest opioid agonist therapy may reduce the incidence of HCV …

Naloxone is a well-established essential medicine for the treatment of life-threatening
heroin/opioid overdose in emergency medicine. Over two decades, the concept of 'take …

Background Opioid overdose is a major cause of mortality, but injury and fatal outcomes can
be prevented by timely administration of the opioid antagonist naloxone. Pre-provision of …