The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …

Tuberculosis continues to cause an unacceptably high toll of disease and death among
children worldwide, particularly in the wake of the HIV epidemic. Increased international …

A series of epidemiological explorations has suggested a negative association between
national bacillus Calmette–Guérin (BCG) vaccination policy and the prevalence and …

The factors that govern the development of tuberculosis disease are incompletely
understood. We hypothesized that some strains of Mycobacterium tuberculosis (M …

The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Abstract Hydrogen peroxide (H2O2) has been implicated in the regulation of the
transcription factor NF-κB, a key regulator of the inflammatory process and adaptive …

Admixed populations present unique opportunities to discover the genetic factors underlying
many multifactorial diseases. The geographical position and complex history of South Africa …

We examined the distribution of single nucleotide polymorphisms (SNPs) in nitric oxide
synthase 2A, monocyte chemoattractant protein–1 (MCP-1), regulated on activation, normal …

Background SARS-CoV-2 causes ongoing pandemic coronavirus disease of 2019 (COVID-
19), infects the cells of the lower respiratory tract that leads to a cytokine storm in a …

Despite the discovery of the tuberculosis (TB) bacillus over 100 years ago and the
availability of effective drugs for over 50 years, there remain a number of formidable …