Epigenetics plays a key role in cellular development and function. Alterations to the epigenome are thought to capture and mediate the effects of genetic and environmental risk …
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …
High costs and technical limitations of cell sorting and single-cell techniques currently restrict the collection of large-scale, cell-type-specific DNA methylation data. This, in turn …
Biodiversity conservation is a global issue where the challenge is to integrate all levels of biodiversity to ensure the long‐term evolutionary potential and resilience of biological …
S Nishitani, M Isozaki, A Yao, Y Higashino… - Translational …, 2023 - nature.com
Neuroepigenetics considers genetic sequences and the interplay with environmental influences to elucidate vulnerability risk for various neurological and psychiatric disorders …
IR Konigsberg, B Barnes, M Campbell… - Communications …, 2021 - nature.com
Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …
Background Socioeconomic position (SEP) is a major determinant of health across the life course. Yet, little is known about the biological mechanisms explaining this relationship. One …
Y Gao, T Sharma, Y Cui - Annual review of biomedical data …, 2023 - annualreviews.org
Artificial intelligence (AI) and other data-driven technologies hold great promise to transform healthcare and confer the predictive power essential to precision medicine. However, the …
IS Muskens, S Li, T Jackson, N Elliot… - Nature …, 2021 - nature.com
Down syndrome is associated with genome-wide perturbation of gene expression, which may be mediated by epigenetic changes. We perform an epigenome-wide association study …