From progenitors to progeny: shaping striatal circuit development and function

R Knowles, N Dehorter, T Ellender - Journal of Neuroscience, 2021 - Soc Neuroscience
Understanding how neurons of the striatum are formed and integrate into complex synaptic
circuits is essential to provide insight into striatal function in health and disease. In this …

[HTML][HTML] Semaphorins and Plexins in central nervous system patterning: the key to it all?

G Limoni, M Niquille - Current Opinion in Neurobiology, 2021 - Elsevier
Highlights•Semaphorins and Plexins are crucial proteins in patterning central nervous
system.•Local and cerebrospinal fluid-derived Semaphorins/Plexins influence …

The nervous system development regulator neuropilin-1 as a potential prognostic marker and therapeutic target in brain cancer

EM Rodrigues, AF Giovanini, CAPM Ribas, O Malafaia… - Cancers, 2023 - mdpi.com
Simple Summary Dysregulation of molecular mechanisms that regulate nervous system
development may be at the origin of brain tumors. We reviewed the role of neuropilin-1 …

Single-cell mapping of brain myeloid cell subsets reveals key transcriptomic changes favoring neuroplasticity after ischemic stroke

F Liu, X Cheng, C Zhao, X Zhang, C Liu, S Zhong… - Neuroscience …, 2024 - Springer
Interactions between brain-resident and peripheral infiltrated immune cells are thought to
contribute to neuroplasticity after cerebral ischemia. However, conventional bulk sequencing …

Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation

ELL Pai, J Chen, S Fazel Darbandi, FS Cho, J Chen… - Elife, 2020 - elifesciences.org
​ Maf (c-Maf) and Mafb transcription factors (TFs) have compensatory roles in repressing
somatostatin (SST+) interneuron (IN) production in medial ganglionic eminence (MGE) …

UTX affects neural stem cell proliferation and differentiation through PTEN signaling

X Lei, J Jiao - Stem cell reports, 2018 - cell.com
Neural stem cell (NSC) proliferation and differentiation in the developing brain is a complex
process precisely regulated by intrinsic and extrinsic signals. Although epigenetic …

Axonal growth of midbrain dopamine neurons is modulated by the cell adhesion molecule ALCAM through trans-heterophilic interactions with L1cam, Chl1, and …

CR Bye, V Rytova, WF Alsanie, CL Parish… - Journal of …, 2019 - Soc Neuroscience
The growth of axons corresponding to different neuronal subtypes is governed by unique
expression profiles of molecules on the growth cone. These molecules respond to …

Deletion of semaphorin 3F in interneurons is associated with decreased GABAergic neurons, autism-like behavior, and increased oxidative stress cascades

Z Li, R Jagadapillai, E Gozal, G Barnes - Molecular Neurobiology, 2019 - Springer
Autism and epilepsy are diseases which have complex genetic inheritance. Genome-wide
association and other genetic studies have implicated at least 500+ genes associated with …

Neuropilin 2 signaling mediates corticostriatal transmission, spine maintenance, and goal-directed learning in mice

M Assous, E Martinez, C Eisenberg, F Shah… - Journal of …, 2019 - Soc Neuroscience
The striatum represents the main input structure of the basal ganglia, receiving massive
excitatory input from the cortex and the thalamus. The development and maintenance of …

A novel SEMA3G mutation in two siblings affected by syndromic GnRH deficiency

R Oleari, V André, A Lettieri, S Tahir, L Roth… - …, 2021 - karger.com
Abstract Introduction: Gonadotropin-releasing hormone (GnRH) deficiency causes
hypogonadotropic hypogonadism (HH), a rare genetic disorder that impairs sexual …