Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system afflicting nearly three million individuals worldwide. Neuroimmune …
Background The dietary consumption of cuprizone–a copper chelator–has long been known to induce demyelination of specific brain structures and is widely used as model of multiple …
C Stadelmann, S Timmler… - Physiological …, 2019 - journals.physiology.org
Oligodendrocytes generate multiple layers of myelin membrane around axons of the central nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …
H Lassmann - Frontiers in immunology, 2019 - frontiersin.org
In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS), which may at later times transform into secondary progressive disease (SPMS). In a minority …
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …
LM Healy, JA Stratton, T Kuhlmann… - Nature Reviews Neurology, 2022 - nature.com
Despite the development of highly effective treatments for relapsing–remitting multiple sclerosis (MS), limited progress has been made in addressing primary progressive or …
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that involves demyelination and axonal degeneration. Although substantial progress has been …
H Lassmann - Cold Spring Harbor perspectives …, 2018 - perspectivesinmedicine.cshlp.org
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to …
N Müller - Schizophrenia bulletin, 2018 - academic.oup.com
This paper discusses the current evidence from animal and human studies for a central role of inflammation in schizophrenia. In animal models, pre-or perinatal elicitation of the immune …