Therapeutic approaches targeting the neurotensin receptors
Introduction: Neurotensin is a gut-brain peptide hormone, a 13 amino acid neuropeptide
found in the central nervous system and in the GI tract. The neurotensinergic system is …
found in the central nervous system and in the GI tract. The neurotensinergic system is …
Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin
Haploinsufficiency of the progranulin protein is a leading cause of frontotemporal lobar
degeneration. Accumulating evidence support a crucial role of progranulin in the lysosome …
degeneration. Accumulating evidence support a crucial role of progranulin in the lysosome …
Rapid traversal of ultralarge chemical space using machine learning guided docking screens
A Luttens, IC de Vaca, L Sparring, U Norinder… - 2023 - chemrxiv.org
The accelerating growth of make-on-demand chemical libraries provides novel opportunities
to identify starting points for drug discovery with virtual screening. However, the recently …
to identify starting points for drug discovery with virtual screening. However, the recently …
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
D Omagari, T Toriumi, H Tsuda, M Hayatsu… - Differentiation, 2023 - Elsevier
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-
derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent …
derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent …
Discovery of Small‐Molecule Inhibitors Targeting Progranulin‐Sortilin: An in‐silico Approach Using Molecular Docking, Molecular Dynamics Simulations, and DFT …
Introduction: Reduction in progranulin (PGRN) have been associated with various
neurodegenerative diseases. PGRN binds with high affinity to sortilin (SORT), a membrane …
neurodegenerative diseases. PGRN binds with high affinity to sortilin (SORT), a membrane …
Discovery of Chemical Probes through Structure-based Virtual Screening of Vast Compound Databases
A Luttens - 2023 - diva-portal.org
Vast Compound Databases. Digital Comprehensive Summaries of Uppsala Dissertations
from the Faculty of Science and Technology 2261. 68 pp. Uppsala: Acta Universitatis …
from the Faculty of Science and Technology 2261. 68 pp. Uppsala: Acta Universitatis …
Discovery of novel small molecule inhibitors targeting progranulin-sortilin: A virtual high throughput screening approach
Introduction: Reduction in progranulin (PGRN) have been associated with various
neurodegenerative diseases. PGRN binds with high affinity to sortilin (SORT), a membrane …
neurodegenerative diseases. PGRN binds with high affinity to sortilin (SORT), a membrane …
A sortilin antagonist for use in the prevention or treatment of hearing loss
MF Kjølby, A Nykjaer, P Little… - US Patent App. 18/030,639, 2023 - Google Patents
The present invention relates to the use of sortilin antagonists, in particular compounds of
Formula (I),(II),(III), and (IV), in the treatment or prevention of hearing loss. Also provided are …
Formula (I),(II),(III), and (IV), in the treatment or prevention of hearing loss. Also provided are …
Methods and Compositions for Treating Lysosomal Storage Disorders
JWCUSQCZMQIBMR-UHFFFAOYSA-N 2-[(6-methylpyridin-2-yl) carbamoyl]-5-
(trifluoromethyl) benzoic acid Chemical compound CC1= CC= CC (NC (= O) C= 2C (= CC …
(trifluoromethyl) benzoic acid Chemical compound CC1= CC= CC (NC (= O) C= 2C (= CC …