Mitochondria are essential organelles in physiology and kidney diseases, because they
produce cellular energy required to perform their function. During mitochondrial metabolism …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

The most problematic issue in clinical nephrology is the relentless and progressive increase
in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic …

Glycative stress, caused by the accumulation of cytotoxic and irreversibly-formed sugar-
derived advanced glycation end-products (AGEs), contributes to morbidity associated with …

Background Allicin is an organosulfur and defensive compound found in garlic (Allium
sativum L.) and other Allium species. Its unique odor is easily detectable, and its effects on …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Oxidative stress has been implicated in the pathophysiology of diabetic nephropathy.
Studies in experimental animal models of diabetes strongly implicate oxidant species as a …

The prevalence of diabetes has dramatically increased worldwide due to the vast increase
in the obesity rate. Diabetic nephropathy is one of the major complications of type 1 and type …