Autophagy and autophagy-related pathways in cancer
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
Balancing lysosome abundance in health and disease
Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired
W Liang, S Sagar, R Ravindran, RH Najor… - Nature …, 2023 - nature.com
Mitochondrial quality control is critical for cardiac homeostasis as these organelles are
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …
A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion
Intracellular degradation of proteins and organelles by the autophagy-lysosome system is
essential for cellular quality control and energy homeostasis. Besides degradation …
essential for cellular quality control and energy homeostasis. Besides degradation …
Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases
The intracellular viral, bacterial, or parasitic pathogens evade the host immune challenges to
propagate and cause fatal diseases. The microbes overpower host immunity at various …
propagate and cause fatal diseases. The microbes overpower host immunity at various …
Autophagy orchestrates the crosstalk between cells and organs
K Piletic, G Alsaleh, AK Simon - EMBO reports, 2023 - embopress.org
Over the recent years, it has become apparent that a deeper understanding of cell‐to‐cell
and organ‐to‐organ communication is necessary to fully comprehend both homeostatic and …
and organ‐to‐organ communication is necessary to fully comprehend both homeostatic and …
Tetracycline antibiotics: Potential anticancer drugs
J Li, Y Qin, C Zhao, Z Zhang, Z Zhou - European journal of pharmacology, 2023 - Elsevier
In recent years, research on tetracycline antibiotics has gradually shifted from their
antibacterial effects to anticancer effects. Doxycycline, minocycline, and tigecycline as the …
antibacterial effects to anticancer effects. Doxycycline, minocycline, and tigecycline as the …
Reduced endosomal microautophagy activity in aging associates with enhanced exocyst‐mediated protein secretion
Autophagy is essential for protein quality control and regulation of the functional proteome.
Failure of autophagy pathways with age contributes to loss of proteostasis in aged …
Failure of autophagy pathways with age contributes to loss of proteostasis in aged …
Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
Y Chen, M Xian, W Ying, J Liu, S Bing, X Wang… - Nature …, 2024 - nature.com
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but
the underlying mechanism remains poorly understood. Given the unique microenvironment …
the underlying mechanism remains poorly understood. Given the unique microenvironment …
The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity
Y Le, Q Liu, Y Yang, J Wu - Cell Death Discovery, 2024 - nature.com
Abstract Nuclear receptor coactivator 4 (NCOA4) has recently been recognized as a
selective cargo receptor of ferritinophagy participating in ferroptosis. However, NCOA4 is …
selective cargo receptor of ferritinophagy participating in ferroptosis. However, NCOA4 is …