Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease
JY Lee, A Martin-Bastida, A Murueta-Goyena… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …
Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions
A Zarkali, GEC Thomas, H Zetterberg… - Nature …, 2024 - nature.com
A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …
A brief history of brain iron accumulation in Parkinson disease and related disorders
Iron has a long and storied history in Parkinson disease and related disorders. This
essential micronutrient is critical for normal brain function, but abnormal brain iron …
essential micronutrient is critical for normal brain function, but abnormal brain iron …
Neuromelanin-sensitive MRI as a promising biomarker of catecholamine function
P Trujillo, MA Aumann, DO Claassen - Brain, 2024 - academic.oup.com
Disruptions to dopamine and noradrenergic neurotransmission are noted in several
neurodegenerative and psychiatric disorders. Neuromelanin-sensitive (NM)-MRI offers a …
neurodegenerative and psychiatric disorders. Neuromelanin-sensitive (NM)-MRI offers a …
Application of neuromelanin MR imaging in Parkinson disease
MRI has been used to develop biomarkers for movement disorders such as Parkinson
disease (PD) and other neurodegenerative disorders with parkinsonism such as progressive …
disease (PD) and other neurodegenerative disorders with parkinsonism such as progressive …
The irony of iron: The element with diverse influence on neurodegenerative diseases
S Lee, GG Kovacs - International Journal of Molecular Sciences, 2024 - mdpi.com
Iron accumulation in the brain is a common feature of many neurodegenerative diseases. Its
involvement spans across the main proteinopathies involving tau, amyloid-beta, alpha …
involvement spans across the main proteinopathies involving tau, amyloid-beta, alpha …
An automatic interpretable deep learning pipeline for accurate Parkinson's disease diagnosis using quantitative susceptibility mapping and T1‐weighted images
Parkinson's disease (PD) diagnosis based on magnetic resonance imaging (MRI) is still
challenging clinically. Quantitative susceptibility maps (QSM) can potentially provide …
challenging clinically. Quantitative susceptibility maps (QSM) can potentially provide …
Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson's disease
Neuromelanin (NM) loss in substantia nigra pars compacta (SNc) and locus coeruleus (LC)
reflects neuronal death in Parkinson's disease (PD). Since genetically-determined PD …
reflects neuronal death in Parkinson's disease (PD). Since genetically-determined PD …
Diagnostic utility of 7T neuromelanin imaging of the substantia nigra in Parkinson's disease
Parkinson's disease (PD) is a prevalent neurodegenerative disorder that presents a
diagnostic challenge due to symptom overlap with other disorders. Neuromelanin (NM) …
diagnostic challenge due to symptom overlap with other disorders. Neuromelanin (NM) …
[HTML][HTML] Diagnosing Parkinson's disease by combining neuromelanin and iron imaging features using an automated midbrain template approach
Background and purpose Early diagnosis of Parkinson's disease (PD) is still a clinical
challenge. Most previous studies using manual or semi-automated methods for segmenting …
challenge. Most previous studies using manual or semi-automated methods for segmenting …