C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …

Conspectus Cross-coupling methods are the most widely used synthetic methods in
medicinal chemistry. Existing reactions are dominated by methods such as amide coupling …

Copper-catalyzed radical-relay reactions provide a versatile strategy for selective C–H
functionalization; however, reactions with peroxide-based oxidants often require excess C …

Site-selective radical reactions of benzylic C–H bonds are now highly effective methods for
C (sp3–H) functionalization and cross-coupling. The existing methods, however, are often …

A visible-light photoredox-catalyzed method is reported that enables the coupling between
benzylic C–H substrates and N–H azoles. Classically, medicinally relevant N-benzyl azoles …

Functionalization of the benzylic C (sp 3)–H bond has become a compelling and robust tool
to speed up pre-clinical research for" lead discovery." Besides bring frequently utilizated to …

We report a visible-light photoredox-catalyzed method that enables nucleophilic amination
of primary and secondary benzylic C (sp3)–H bonds. A novel amidyl radical precursor and …

Chiral N-cyclopropyl pyrazoles and structurally related heterocycles are prepared using an
earth-abundant copper catalyst under mild reaction conditions with high regio-, diastereo …

Herein, we describe the development of a copper‐catalyzed C (sp3)‐amination of
proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the …

Chiral benzylic amines are privileged motifs in pharmacologically active molecules.
Intramolecular enantioselective radical C (sp3)− H functionalization by hydrogen‐atom …