The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

Autophagy is a highly conserved process and is essential for the maintenance of cellular
homeostasis. Autophagy occurs at a basal level in all cells, but it can be up-regulated during …

Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …

Abstract Purpose of Review The global prevalence of type 2 diabetes (T2D) is escalating at
alarming rates, demanding the development of additional classes of therapeutics to further …

Highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR)
and AMP-activated protein kinase (AMPK) are central to cellular metabolism and cell …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

The adenosine monophosphate‐activated protein kinase (AMPK) is an integrative metabolic
sensor that maintains energy balance at the cellular level and plays an important role in …