Working memory control dynamics follow principles of spatial computing

M Lundqvist, SL Brincat, J Rose, MR Warden… - Nature …, 2023 - nature.com
Working memory (WM) allows us to remember and selectively control a limited set of items.
Neural evidence suggests it is achieved by interactions between bursts of beta and gamma …

Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia

U Braun, A Harneit, G Pergola, T Menara… - Nature …, 2021 - nature.com
Dynamical brain state transitions are critical for flexible working memory but the network
mechanisms are incompletely understood. Here, we show that working memory …

Timescales of learning in prefrontal cortex

JA Miller, C Constantinidis - Nature Reviews Neuroscience, 2024 - nature.com
The lateral prefrontal cortex (PFC) in humans and other primates is critical for immediate,
goal-directed behaviour and working memory, which are classically considered distinct from …

[HTML][HTML] Working memory: from neural activity to the sentient mind

RJ Jaffe, C Constantinidis - Comprehensive Physiology, 2021 - ncbi.nlm.nih.gov
Working memory is the ability to maintain and manipulate information in the conscious mind
over a timescale of seconds. This ability is thought to be maintained through the persistent …

Differential coding of goals and actions in ventral and dorsal corticostriatal circuits during goal-directed behavior

H Tang, VD Costa, R Bartolo, BB Averbeck - Cell reports, 2022 - cell.com
Goal-directed behavior requires identifying objects in the environment that can satisfy
internal needs and executing actions to obtain those objects. The current study examines …

Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses

H Tang, R Bartolo, BB Averbeck - Neuron, 2024 - cell.com
Reinforcement learning (RL), particularly in primates, is often driven by symbolic outcomes.
However, it is usually studied with primary reinforcers. To examine the neural mechanisms …

Prefrontal cortical plasticity during learning of cognitive tasks

H Tang, MR Riley, B Singh, XL Qi, DT Blake… - Nature …, 2022 - nature.com
Training in working memory tasks is associated with lasting changes in prefrontal cortical
activity. To assess the neural activity changes induced by training, we recorded single units …

Long-term learning transforms prefrontal cortex representations during working memory

JA Miller, A Tambini, A Kiyonaga, M D'Esposito - Neuron, 2022 - cell.com
The role of the lateral prefrontal cortex (lPFC) in working memory (WM) is debated. Non-
human primate (NHP) electrophysiology shows that the lPFC stores WM representations, but …

Cognitive strategies shift information from single neurons to populations in prefrontal cortex

FK Chiang, JD Wallis, EL Rich - Neuron, 2022 - cell.com
Neurons in primate lateral prefrontal cortex (LPFC) play a critical role in working memory
(WM) and cognitive strategies. Consistent with adaptive coding models, responses of these …

Melamine impairs working memory and reduces prefrontal activity associated with inhibition of AMPA receptor GluR2/3 subunit expression

W Sun, D Tang, Y Yang, Z Wu, X Li, L An - Toxicology Letters, 2021 - Elsevier
Recent studies have reported that melamine can accumulate in several regions of the brain
including the medial prefrontal cortex (mPFC). Although melamine accumulation in the …