The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …
tuberculosis remains out of control in several parts of the world including Africa and Asia …
Machine learning and applications in microbiology
SJ Goodswen, JLN Barratt, PJ Kennedy… - FEMS microbiology …, 2021 - academic.oup.com
To understand the intricacies of microorganisms at the molecular level requires making
sense of copious volumes of data such that it may now be humanly impossible to detect …
sense of copious volumes of data such that it may now be humanly impossible to detect …
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis
P Miotto, B Tessema, E Tagliani… - European …, 2017 - Eur Respiratory Soc
A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium
tuberculosis is required to accelerate the development of rapid drug susceptibility testing …
tuberculosis is required to accelerate the development of rapid drug susceptibility testing …
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid …
Background Improved genetic understanding of Mycobacterium tuberculosis (MTB)
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …
Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms
CRyPTIC Consortium - PLoS biology, 2022 - journals.plos.org
The emergence of drug-resistant tuberculosis is a major global public health concern that
threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly …
threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly …
Genomic characterization of nontuberculous mycobacteria
T Fedrizzi, CJ Meehan, A Grottola, E Giacobazzi… - Scientific reports, 2017 - nature.com
Mycobacterium tuberculosis and Mycobacterium leprae have remained, for many years, the
primary species of the genus Mycobacterium of clinical and microbiological interest. The …
primary species of the genus Mycobacterium of clinical and microbiological interest. The …
A fast and agnostic method for bacterial genome-wide association studies: Bridging the gap between k-mers and genetic events
Genome-wide association study (GWAS) methods applied to bacterial genomes have
shown promising results for genetic marker discovery or detailed assessment of marker …
shown promising results for genetic marker discovery or detailed assessment of marker …
GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions
Drug resistance diagnostics that rely on the detection of resistance-related mutations could
expedite patient care and TB eradication. We perform minimum inhibitory concentration …
expedite patient care and TB eradication. We perform minimum inhibitory concentration …
Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study
Background In many countries, regular monitoring of the emergence of resistance to anti-
tuberculosis drugs is hampered by the limitations of phenotypic testing for drug …
tuberculosis drugs is hampered by the limitations of phenotypic testing for drug …
Drug-resistant tuberculosis: a persistent global health concern
Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …