Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies
IRA Mackenzie, M Neumann - Journal of neurochemistry, 2016 - Wiley Online Library
Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. The past decade has seen the discovery of several new FTD‐causing genetic …
basis. The past decade has seen the discovery of several new FTD‐causing genetic …
Frontotemporal dementia: latest evidence and clinical implications
JJ Young, M Lavakumar, D Tampi… - Therapeutic …, 2018 - journals.sagepub.com
Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive
syndromes that present with impairment of executive functioning, changes in behavior, and …
syndromes that present with impairment of executive functioning, changes in behavior, and …
C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis
C9orf72 hexanucleotide repeat expansions are the most common cause of familial
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) worldwide. The …
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) worldwide. The …
An update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations
The development of our understanding of frontotemporal dementia (FTD) has gathered pace
over the last 10 years. After taking a back seat to A lzheimer's disease for many years FTD …
over the last 10 years. After taking a back seat to A lzheimer's disease for many years FTD …
The clinical spectrum of sporadic and familial forms of frontotemporal dementia
IOC Woollacott, JD Rohrer - Journal of neurochemistry, 2016 - Wiley Online Library
The term frontotemporal dementia (FTD) describes a clinically, genetically and
pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present …
pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present …
The widening spectrum of C9ORF72-related disease; genotype/phenotype correlations and potential modifiers of clinical phenotype
Abstract The GGGGCC (G 4 C 2) repeat expansion in C9ORF72 is the most common cause
of familial amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia (FTLD) and …
of familial amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia (FTLD) and …
Progranulin in neurodegenerative disease
TL Petkau, BR Leavitt - Trends in neurosciences, 2014 - cell.com
Loss-of-function mutations in the progranulin gene are a common cause of familial
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …
Defining the genetic connection linking amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD)
Several genetic causes have been recently described for neurological diseases, increasing
our knowledge of the common pathological mechanisms involved in these disorders …
our knowledge of the common pathological mechanisms involved in these disorders …
Phenotypic heterogeneity of monogenic frontotemporal dementia
Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous disorder
characterized by personality changes, language impairment, and deficits of executive …
characterized by personality changes, language impairment, and deficits of executive …
Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
YS Davidson, H Barker, AC Robinson… - Acta neuropathologica …, 2014 - Springer
A hexanucleotide (GGGGCC) expansion in C9ORF72 gene is the most common genetic
change seen in familial Frontotemporal Lobar Degeneration (FTLD) and familial Motor …
change seen in familial Frontotemporal Lobar Degeneration (FTLD) and familial Motor …