Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the
organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a …

Progress in the mechanism and targeted drug therapy for COPD

C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …

Association of β-blocker use with survival and pulmonary function in patients with chronic obstructive pulmonary and cardiovascular disease: a systematic review and …

YL Yang, ZJ Xiang, JH Yang, WJ Wang… - European heart …, 2020 - academic.oup.com
Aims The aim of this study was to clarify the effect of β-blockers (BBs) on respiratory function
and survival in patients with chronic obstructive pulmonary disease with cardiovascular …

COPD exacerbations· 2: aetiology

E Sapey, RA Stockley - Thorax, 2006 - thorax.bmj.com
Exacerbations of COPD are thought to be caused by complex interactions between the host,
bacteria, viruses, and environmental pollution. These factors increase the inflammatory …

Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy

D Stolz, M Christ-Crain, R Bingisser, J Leuppi… - Chest, 2007 - Elsevier
Background: Therapy with antibiotics influences recovery only in selected cases of COPD
exacerbations. We evaluated the efficacy and safety of procalcitonin guidance compared to …

Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease

JR Hurst, GC Donaldson, WR Perera… - American journal of …, 2006 - atsjournals.org
Impact: This study explores the use of measuring plasma biomarkers at exacerbation of
chronic obstructive pulmonary disease (COPD), providing insight into the underlying …

Systemic effects in COPD

EFM Wouters, EC Creutzberg, AMWJ Schols - Chest, 2002 - Elsevier
The pathogenesis and clinical manifestations of COPD are not restricted to pulmonary
inflammation and structural remodeling. Rather, this disorder is associated with clinically …

Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease

JR Hurst, WR Perera, TMA Wilkinson… - American journal of …, 2006 - atsjournals.org
Rationale: In addition to pulmonary involvement, stable chronic obstructive pulmonary
disease (COPD) is associated with nasal and systemic inflammation. Although …

Cytokine inhibition in the treatment of COPD

G Caramori, IM Adcock, A Di Stefano… - International journal of …, 2014 - Taylor & Francis
Cytokines play an important part in many pathobiological processes of chronic obstructive
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …

[引用][C] Mediators of chronic obstructive pulmonary disease

PJ Barnes - Pharmacological reviews, 2004 - ASPET