The rapid growth of the number of protein sequences that can be inferred from sequenced
genomes presents challenges for function assignment, because only a small fraction …

Dihydropyrimidinase (DHPase) is a key enzyme in the pyrimidine pathway, the catabolic
route for synthesis of β-amino acids. It catalyses the reversible conversion of 5, 6 …

Structural and functional studies require the development of sophisticatedBig
Data'technologies and software to increase the knowledge derived and ensure …

Terpenoid synthases construct the carbon skeletons of tens of thousands of natural
products. To predict functions and specificity of triterpenoid synthases, a mechanism-based …

Zinc-dependent medium chain reductase from Candida parapsilosis can be used in the
reduction of carbonyl compounds to pharmacologically important chiral secondary alcohols …

With few exceptions protein functions depend sensitively upon their interactions with other
biomolecules. Thus, the surface of a protein is of particular interest for function annotation …

O entendimento de reações enzimáticas em nível atômico é um dos maiores desafios para
a biofísica moderna1. Técnicas experimentais como a difração de raios X e engenharia …

Les micro-organismes aussi appelés microbes, forment un ensemble d'organismes vivants
microscopiques, invisibles à l'œil nu. Ceci est leur seul point commun, car ils diffèrent et …

This thesis aims to investigate the carbonyl reduction mechanism and substrate specificity of
carbonyl reductase 2 from Candida parapsilosis (CPCR2). Chapter 1 involves the …