Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Importance Normal thyroid gland function is critical for early neurocognitive development, as
well as for growth and development throughout childhood and adolescence. Thyroid …

The Japan Gastroenterological Endoscopy Society developed the Guideline for Endoscopic
Diagnosis of Early Gastric Cancer based on scientific methods. Endoscopy for the diagnosis …

Hereditary gastrointestinal cancer predisposition syndromes have been well characterized,
but management strategies and surveillance remain a major challenge, especially in …

Several distinct melanoma syndromes have been defined, and genetic tests are available
for the associated causative genes. Guidelines for melanoma genetic testing have been …

Recent advancements in next-generation sequencing have greatly expanded the use of
multi-gene panel testing for hereditary cancer risk. Although genetic testing helps guide …

Colorectal cancer is one of the most common tumors, and genetic predisposition is one of
the key risk factors in the development of this malignancy. Lynch syndrome and familial …

Background Multigene panels can be a cost-and time-effective alternative to sequentially
testing multiple genes, especially with a mixed family cancer phenotype. However, moving …

Patients with hereditary gastrointestinal (GI) cancers represent a substantial fraction of the
overall affected population. Although awareness for hereditary GI cancer syndromes is on …

Most patients with thyroid cancer are asymptomatic at the time of diagnosis even in the
presence of regional or distant metastasis. More than 85% of childhood thyroid carcinomas …