Intellectual disability: dendritic anomalies and emerging genetic perspectives

TT Quach, HJ Stratton, R Khanna, PE Kolattukudy… - Acta …, 2021 - Springer
Intellectual disability (ID) corresponds to several neurodevelopmental disorders of
heterogeneous origin in which cognitive deficits are commonly associated with …

NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

R Zhang, W Mao, L Niu, W Bao, Y Wang, Y Wang… - Elife, 2023 - elifesciences.org
Transplantation of neural stem cells (NSCs) has been proved to promote functional
rehabilitation of brain lesions including ischemic stroke. However, the therapeutic effects of …

Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway

X Jiang, S Yi, Q Liu, D Su, L Li, C Xiao… - Journal of …, 2022 - Springer
Background The natural compound asperosaponin VI has shown potential as an
antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to …

Effect of exercise on cognitive function and synaptic plasticity in Alzheimer's disease models: A systematic review and meta-analysis

L Guo, X Yang, Y Zhang, X Xu, Y Li - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Introduction Cognitive decline is a central manifestation of Alzheimer's disease (AD), and its
process is inseparable from changes in synaptic plasticity. The aim of this review was to …

β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway

Z Ning, X Zhong, Y Wu, Y Wang, D Hu, K Wang… - Phytomedicine, 2024 - Elsevier
Background Vascular dementia (VD) is the second most common type of dementia after
Alzheimer's disease. β-asarone, a major component of Acorus tatarinowii Schott, is …

Repeated exposure to propofol in the neonatal period impairs hippocampal synaptic plasticity and the recognition function of rats in adulthood

J Wan, CM Shen, Y Wang, QZ Wu, YL Wang, Q Liu… - Brain Research …, 2021 - Elsevier
Anesthesia of neonates with propofol induces persistent behavioral abnormalities in
adulthood. Although propofol-triggered apoptosis of neurons in the developing brain may …

Panax notoginseng Saponins Stimulates Neurogenesis and Neurological Restoration After Microsphere-Induced Cerebral Embolism in Rats Partially Via mTOR …

J Gao, J Liu, M Yao, W Zhang, B Yang… - Frontiers in …, 2022 - frontiersin.org
P. Notoginseng Saponins (PNS), the main active component of herbal medicine Panax
notoginseng, has been widely used to treat cerebrovascular diseases. It has been …

Nanoarchitectonics of tannic acid based injectable hydrogel regulate the microglial phenotype to enhance neuroplasticity for poststroke rehabilitation

Z Liu, S Zhang, Y Ran, H Geng, F Gao, G Tian… - Biomaterials …, 2023 - spj.science.org
Background Stroke is the second leading cause of mortality and disability worldwide.
Poststroke rehabilitation is still unsatisfactory in clinics, which brings great pain and …

MiR-153 downregulation alleviates PTSD-like behaviors and reduces cell apoptosis by upregulating the Sigma-1 receptor in the hippocampus of rats exposed to …

YL Chen, L Tong, Y Chen, CH Fu, JB Peng, LL Ji - Experimental neurology, 2022 - Elsevier
Posttraumatic stress disorder (PTSD) is a psychiatric disorder that may lead to a series of
changes in the central nervous system, including impaired synaptic plasticity, neuronal …

[HTML][HTML] Prenatal benzo [a] pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via …

Y Zhang, L Du, J Yan, Q Bai, Q Niu, Y Mo… - Ecotoxicology and …, 2022 - Elsevier
Abstract Benzo [a] pyrene (B [a] P) is a widespread carcinogenic pollutant in the
environment. Although previous studies have demonstrated the neurodevelopmental toxicity …