[HTML][HTML] Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
[HTML][HTML] 3D in vitro model (R) evolution: unveiling tumor–stroma interactions
The complex microenvironment in which malignant tumor cells grow is crucial for cancer
progression. The physical and biochemical characteristics of this niche are involved in …
progression. The physical and biochemical characteristics of this niche are involved in …
[HTML][HTML] Three-dimensional spheroids as in vitro preclinical models for cancer research
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
Microfluidics for drug development: from synthesis to evaluation
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …
delivery, and drug evaluation. Compared with conventional drug development procedures …
[HTML][HTML] Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy
Z Liu, Z Zhou, Q Dang, H Xu, J Lv, H Li, X Han - Theranostics, 2022 - ncbi.nlm.nih.gov
Chimeric antigen receptor (CAR)-T cell therapy represents a landmark advance in
personalized cancer treatment. CAR-T strategy generally engineers T cells from a specific …
personalized cancer treatment. CAR-T strategy generally engineers T cells from a specific …
[HTML][HTML] 3D tumor models and their use for the testing of immunotherapies
Over the past decade, immunotherapy has become a powerful and evident tool in the fight
against cancers. Notably, the rise of checkpoint blockade using monoclonal antibodies (anti …
against cancers. Notably, the rise of checkpoint blockade using monoclonal antibodies (anti …
Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies
In vitro 3D models are advanced biological tools that have been established to overcome
the shortcomings of oversimplified 2D cultures and mouse models. Various in vitro 3D …
the shortcomings of oversimplified 2D cultures and mouse models. Various in vitro 3D …
Advances in organ-on-a-chip materials and devices
The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …
modulating patients' own immune systems and unleashing pre-existing immunity. However …
[HTML][HTML] Organoids and organs-on-chips: insights into predicting the efficacy of systemic treatment in colorectal cancer
J Zhu, L Ji, Y Chen, H Li, M Huang, Z Dai, J Wang… - Cell Death …, 2023 - nature.com
Cancer heterogeneity has posed a great challenge to traditional cancer treatment, with the
reappearance of cancer heterogeneity of inter and intra patients being especially critical …
reappearance of cancer heterogeneity of inter and intra patients being especially critical …