The gut–joint axis in rheumatoid arthritis

MM Zaiss, HJ Joyce Wu, D Mauro, G Schett… - Nature Reviews …, 2021 - nature.com
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …

Psoriatic arthritis from a mechanistic perspective

G Schett, P Rahman, C Ritchlin, IB McInnes… - Nature Reviews …, 2022 - nature.com
Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

[HTML][HTML] Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies

JMGR de Morales, L Puig, E Daudén, JD Cañete… - Autoimmunity …, 2020 - Elsevier
Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

G Schett, MF Neurath - Nature communications, 2018 - nature.com
Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

Psoriatic arthritis: pathogenesis and targeted therapies

AB Azuaga, J Ramírez, JD Cañete - International journal of molecular …, 2023 - mdpi.com
Psoriatic arthritis (PsA), a heterogeneous chronic inflammatory immune-mediated disease
characterized by musculoskeletal inflammation (arthritis, enthesitis, spondylitis, and …

Skin and gut microbiome in psoriasis: gaining insight into the pathophysiology of it and finding novel therapeutic strategies

L Chen, J Li, W Zhu, Y Kuang, T Liu, W Zhang… - Frontiers in …, 2020 - frontiersin.org
Psoriasis affects the health of myriad populations around the world. The pathogenesis is
multifactorial, and the exact driving factor remains unclear. This condition arises from the …

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

DG McGonagle, IB McInnes, BW Kirkham… - Annals of the …, 2019 - ard.bmj.com
Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …

Spondyloarthritis with inflammatory bowel disease: the latest on biologic and targeted therapies

G Cozzi, L Scagnellato, M Lorenzin… - Nature Reviews …, 2023 - nature.com
Spondyloarthritis (SpA) encompasses a heterogeneous group of chronic inflammatory
diseases that can affect both axial and peripheral joints, tendons and entheses. Among the …

The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis

H Tsukazaki, T Kaito - International Journal of Molecular Sciences, 2020 - mdpi.com
Spondyloarthritis (SpA) is a subset of seronegative rheumatic-related autoimmune diseases
that consist of ankylosing spondylitis (AS), psoriatic spondylitis (PsA), reactive spondylitis (re …

IL-17 in the immunopathogenesis of spondyloarthritis

LS Taams, KJA Steel, U Srenathan, LA Burns… - Nature reviews …, 2018 - nature.com
Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes
psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic …