The cGAS-STING (cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes
(STING)) axis integrates DNA damage and cellular stress with type I interferon (IFN) …

Single-cell technologies have transformed biomedical research over the last decade,
opening up new possibilities for understanding cellular heterogeneity, both at the genomic …

Improved biomarkers are needed for early cancer detection, risk stratification, treatment
selection, and monitoring treatment response. Although proteins can be useful blood-based …

Transcribed enhancer maps can reveal nuclear interactions underpinning each cell type
and connect specific cell types to diseases. Using a 5′ single-cell RNA sequencing …

Long interspersed nuclear elements (LINE-1s/L1s) are a group of retrotransposons that can
copy themselves within a genome. In humans, it is the most successful transposon in …

Retrotransposable elements (RTEs) are genetic elements that can replicate and insert new
copies into different genomic locations. RTEs have long been identified as 'parasitic genes' …

Cervical intraepithelial neoplasia (CIN) represents a spectrum of preinvasive squamous
lesions within the cervical epithelium, whose identification is a diagnostic challenge due to …

抗肿瘤治疗已进入靶向治疗和免疫治疗的精准治疗时代, 这对指导抗肿瘤治疗和监测肿瘤治疗
反应的生物标志物提出了更高的要求. 本文对2023 年取得较大进展的肿瘤蛋白生物标志物进行 …

Recent studies have established a reciprocal causal link between aging and the activation
of transposable elements, characterized in particular by a de-repression of LINE-1 …

Abstract The Greenland shark (Somniosus microcephalus) is an enigmatic species known
for its exceptional longevity and extraordinary adaptations to the cold environment. This …