Leishmania is a protozoan parasite of the trypanosomatid family, causing a wide range of
diseases with different clinical manifestations including cutaneous, mucocutaneous and …

Almost all bacteria synthesize two types of toxins—one for its survival by regulating different
cellular processes and another as a strategy to interact with host cells for pathogenesis …

Emerging Artemisinin (ART) resistance in Plasmodium falciparum (Pf) poses challenges for
the discovery of novel drugs to tackle ART-resistant parasites. Concentrated efforts toward …

The Leishmania donovani species complex is the causative agent of visceral leishmaniasis,
which cause 20–40,000 fatalities a year. Here, we conduct a screen for balancing selection …

Toxin–antitoxin (TA) systems are genetic modules composed of a toxin interfering with
cellular processes and its cognate antitoxin, which counteracts the activity of the toxin. TA …

The majority of bacteria and archaea contains Toxin‐Antitoxin system (TA) that codes for the
stable Toxin and unstable Antitoxin components forming a complex. The Antitoxin inhibits …

Available anti-leishmanial drugs are associated with toxic side effects, necessitating the
search for safe and effective alternatives. This study is focused on identifying traditional …

Abstract Iron-sulfur (Fe-S) cluster containing proteins have been assigned roles in various
essential cellular processes, such as regulation of gene expression, electron transfer …

Objective: To evaluate the efficacy and immunogenicity of the zeta domain over-expressing
Leishmania donovani (Ld_ζ1domain) as a vaccination candidate against visceral …

The intraerythrocytic growth of malaria parasite is challenged by the presence of proteotoxic
stress and intrinsically unstructured proteins in the cytoplasm due to formation of toxic heme …