The endolysosomal system comprises a dynamic constellation of vesicles working together
to sense and interpret environmental cues and facilitate homeostasis. Integrating …

The cell is comprised of integrated multilevel protein networks or systems. The ubiquitin,
protein homeostasis and membrane trafficking systems are highly integrated. Here, we look …

Tumor metastasis is a leading cause of death in lung adenocarcinoma (LUAD) patients, but
the molecular events that regulate metastasis have not been completely elucidated …

Endocytic down-regulation of cell-surface proteins is a fundamental cellular process for cell
survival and adaptation to environmental stimuli. Ubiquitination of cargo proteins serves as …

Ubiquitination is a crucial posttranslational protein modification involved in a myriad of
biological pathways. This modification is reversed by deubiquitinases (DUBs) that …

In recent times, our knowledge of the roles ubiquitin plays in multiple cellular processes has
expanded exponentially, with one example being the role of ubiquitin in receptor …

AMSH [associated molecule with a Src homology 3 domain of signal transducing adaptor
molecule (STAM)] is one of the deubiquitinating enzymes associated in the regulation of …

Multidomain proteins represent a broad spectrum of the protein landscape and are involved
in various interactions. They could be considered as modular building blocks assembled in …

Ubiquitination is an important protein post-translational modification that is essential for
almost all cellular processes in human cells. The reverse process, deubiquitination is …

The protein RP2 is a tubulin cofactor C-domain containing protein with important roles in
ciliogenesis. In humans, mutations in the RP2 gene are associated with 10-15% of cases of …