The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

BD Fontana, NJ Mezzomo, AV Kalueff… - Experimental …, 2018 - Elsevier
Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …

Zebrafish models in neuropsychopharmacology and CNS drug discovery

KM Khan, AD Collier, DA Meshalkina… - British journal of …, 2017 - Wiley Online Library
Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …

Past, present and future of zebrafish in epilepsy research

E Yaksi, A Jamali, C Diaz Verdugo… - The FEBS …, 2021 - Wiley Online Library
Animal models contribute greatly to our understanding of brain development and function as
well as its dysfunction in neurological diseases. Epilepsy research is a very good example of …

A pharmacological basis of herbal medicines for epilepsy

NJ Sucher, MC Carles - Epilepsy & Behavior, 2015 - Elsevier
Epilepsy is the most common chronic neurological disease, affecting about 1% of the world's
population during their lifetime. Most people with epilepsy can attain a seizure-free life upon …

[HTML][HTML] Opportunities for improving animal welfare in rodent models of epilepsy and seizures

K Lidster, JG Jefferys, I Blümcke, V Crunelli… - Journal of neuroscience …, 2016 - Elsevier
Animal models of epilepsy and seizures, mostly involving mice and rats, are used to
understand the pathophysiology of the different forms of epilepsy and their comorbidities, to …

[HTML][HTML] Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review

B Knap, D Nieoczym, U Kundap… - Frontiers in Molecular …, 2023 - frontiersin.org
Traditionally, selected plant sources have been explored for medicines to treat convulsions.
This continues today, especially in countries with low-income rates and poor medical …

Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity

AL Hotz, A Jamali, NN Rieser, S Niklaus, E Aydin… - Glia, 2022 - Wiley Online Library
Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the
duration and extent of neuronal excitation by removing glutamate from the synaptic cleft …

[HTML][HTML] Use of zebrafish models to boost research in rare genetic diseases

L Crouzier, EM Richard, J Sourbron, L Lagae… - International journal of …, 2021 - mdpi.com
Rare genetic diseases are a group of pathologies with often unmet clinical needs. Even if
rare by a single genetic disease (from 1/2000 to 1/more than 1,000,000), the total number of …

Functional analysis of epilepsy‐associated variants in STXBP1/Munc18‐1 using humanized Caenorhabditis elegans

B Zhu, JCH Mak, AP Morris, AG Marson, JW Barclay… - …, 2020 - Wiley Online Library
Objective Genetic variants in STXBP1, which encodes the conserved exocytosis protein
Munc18‐1, are associated with a variety of infantile epilepsy syndromes. We aimed to …

[HTML][HTML] Toward the use of novel alternative methods in epilepsy modeling and drug discovery

C Miguel Sanz, M Martinez Navarro… - Frontiers in …, 2023 - frontiersin.org
Epilepsy is a chronic brain disease and, considering the amount of people affected of all
ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure …