Mechanisms of modulation of mitochondrial architecture

JP Muñoz, FL Basei, ML Rojas, D Galvis, A Zorzano - Biomolecules, 2023 - mdpi.com
Mitochondrial network architecture plays a critical role in cellular physiology. Indeed,
alterations in the shape of mitochondria upon exposure to cellular stress can cause the …

Dynamic death decisions: How mitochondrial dynamics shape cellular commitment to apoptosis and ferroptosis

J Khatun, JD Gelles, JE Chipuk - Developmental Cell, 2024 - cell.com
The incorporation of mitochondria into early eukaryotes established organelle-based
biochemistry and enabled metazoan development. Diverse mitochondrial biochemistry is …

Role of mitochondria in the regulation of ferroptosis and disease

C Fu, N Cao, S Zeng, W Zhu, X Fu, W Liu… - Frontiers in Medicine, 2023 - frontiersin.org
Ferroptosis is a distinctive form of iron-dependent cell death characterized by significant
ultrastructural changes in mitochondria. Given the crucial involvement of mitochondria in …

Non-Vesicular Lipid Transport Machinery in Leishmania donovani: Functional Implications in Host-Parasite Interaction

K Das, T Nozaki - International Journal of Molecular Sciences, 2023 - mdpi.com
Eukaryotic cells have distinct membrane-enclosed organelles, each with a unique
biochemical signature and specialized function. The unique identity of each organelle is …

Kechuan Decoction mitigates apoptosis of airway epithelial cells by improving lipid metabolism disorders and mitochondria dysfunction in HDM-induced asthma

B Zhao, C Shi, X Wang, Z Sun, Y Ruan, X Wang… - Phytomedicine, 2025 - Elsevier
Background The airway epithelium serves as the first line of defense between the lung's
internal environment and the external environment, functioning through physical barriers …

Ferroptosis in Cardiovascular Disease and Cardiomyopathies: Therapeutic Implications of Glutathione and Iron Chelating Agents

J Dawi, S Affa, E Gonzalez, Y Misakyan… - Biomedicines, 2024 - mdpi.com
This review explores ferroptosis, a form of regulated cell death reliant on iron-induced
phospholipid peroxidation, in diverse physiological and pathological contexts, including …

Targeting mitochondrial homeostasis in the treatment of non-alcoholic fatty liver disease: a review

Y Deng, Y Dong, S Zhang, Y Feng - Frontiers in Pharmacology, 2024 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and its prevalence is rapidly increasing. Antioxidants, lipid-lowering medications …

StarD7 deficiency switches on glycolysis and promotes mitophagy flux in C2C12 myoblasts

ML Rojas, JP Muñoz, J Flores‐Martín… - The FEBS …, 2024 - Wiley Online Library
StarD7 is a member of the START protein family required for phosphatidylcholine delivery to
the mitochondria, thus key to maintain mitochondrial structure. Its deficiency has been …

Krüppel‐like factor 6 participates in extravillous trophoblast cell differentiation and its expression is reduced in abnormally invasive placenta

AL Miranda, LT Kourdova, AC Racca… - FEBS …, 2022 - Wiley Online Library
Trophoblast cell differentiation is of paramount importance for successful pregnancy.
Krüppel‐like factor 6 (KLF6), a transcription factor with diverse roles in cell physiology and …

Non-vesicular Lipid Transport Machinery in Trichomonas vaginalis: Novel Drug Targets against Trichomoniasis

K Das, SB Rahaman, S Upadhyay… - Current Topics in …, 2023 - benthamdirect.com
Eukaryotic cells have separate membrane-enclosed organelles with distinct biochemical
identities and specialized functions. The unique characteristics of each organelle are …